Nick Andrews joined the Health Protection Agency in the UK in 1993 after completing a BSc mathematics & statistics and an MSc in medical statistics at Reading University. His early work at the HPA was mainly in the area of outbreak detection and investigation, laboratory method comparisons and seroepidemiology. In 1998 he became the statistician responsible for work in the immunisation department of the HPA. In this role he has worked extensively on post licensure vaccine safety and effectiveness assessment, clinical trials and correlates of protection. Publications have included looking at MMR and autism, thiomersal in vaccines and developmental problems, new methods for estimating pneumococcal and influenza vaccine effectiveness and assessment of meningococcal group C correlates of protection. He is currently a partner in European projects on vaccine safety and effectiveness, a WHO measles clinical trial and a global vaccine saftey initiative. In the past year he has been involved in many influenza pandemic projects including a clinical trial in children, rapid vaccine effectiveness estimation and incidence estimation using seroepidemiology. He has over 150 publications with more than half of these in the vaccine field.